Endurant Types in Ontology-Driven Conceptual Modeling: Towards OntoUML 2.0

For over a decade now, a community of researchers has contributed to the development of the Unified Foundational Ontology (UFO) - aimed at providing foundations for all major conceptual modeling constructs. This ontology has led to the development of an Ontology-Driven Conceptual Modeling language dubbed OntoUML, reflecting the ontological micro-theories comprising UFO. Over the years, UFO and OntoUML have been successfully employed in a number of academic, industrial and governmental settings to create conceptual models in a variety of different domains. These experiences have pointed out to opportunities of improvement not only to the language itself but also to its underlying theory. In this paper, we take the first step in that direction by revising the theory of types in UFO in response to empirical evidence. The new version of this theory shows that many of the meta-types present in OntoUML (differentiating Kinds, Roles, Phases, Mixins, etc.) should be considered not as restricted to Substantial types but instead should be applied to model Endurant Types in general, including Relator types, Quality types and Mode types. We also contribute a formal characterization of this fragment of the theory, which is then used to advance a metamodel for OntoUML 2.0. Finally, we propose a computational support tool implementing this updated metamodel

Precise determination of muon and electromagnetic shower contents from shower universality property

We consider two new aspects of Extensive Air Shower development universality allowing to make accurate estimation of muon and electromagnetic (EM) shower contents in two independent ways. In the first case, to get muon (or EM) signal in water Cherenkov tanks or in scintillator detectors it is enough to know the vertical depth of shower maximum and the total signal in the ground detector. In the second case, the EM signal can be calculated from the primary particle energy and the zenith angle. In both cases the parametrizations of muon and EM signals are almost independent on primary particle nature, energy and zenith angle. Implications of the considered properties for mass composition and hadronic interaction studies are briefly discussed. The present study is performed on 28000 of proton, oxygen and iron showers, generated with CORSIKA 6.735 for $E^{-1}$ spectrum in the energy range log(E/eV)=18.5-20.0 and uniformly distributed in cos^2(theta) in zenith angle interval theta=0-65 degrees for QGSJET II/Fluka interaction models.Comment: Submitted to Phys. Rev.

A new multiparametric topological method for determining the primary cosmic ray mass composition in the knee energy region

The determination of the primary cosmic ray mass composition from the characteristics of extensive air showers (EAS), obtained at an observation level in the lower half of the atmosphere, is still an open problem. In this work we propose a new method of the Multiparametric Topological Analysis and show its applicability for the determination of the mass composition of the primary cosmic rays at the PeV energy region.Comment: 8 pages, 4 figures, talk given at Vulcano 2004 Workshop 'Frontier Objects in Physics and Astrophysics', Vulcano, Italy, 24-29.05.04, to be published in the Proceedings of the Worksho

Fluorescence and Hybrid Detection Aperture of the Pierre Auger Observatory

The aperture of the Fluorescence Detector (FD) of the Pierre Auger Observatory is evaluated from simulated events using different detector configurations: mono, stereo, 3-FD and 4-FD. The trigger efficiency has been modeled using shower profiles with ground impacts in the field of view of a single telescope and studying the trigger response (at the different levels) by that telescope and by its neighbours. In addition, analysis cuts imposed by event reconstruction have been applied. The hybrid aperture is then derived for the Auger final extension. Taking into account the actual Surface Detector (SD) array configuration and its trigger response, the aperture is also calculated for a typical configuration of the present phase.Comment: contribution to the 29th International Cosmic Ray Conference, Pune, India, 3-10 August 200

A simplified thermal analysis approach for power transistor rating in PWM-controlled DC/AC converters

A simplified dynamic thermal analysis approach is proposed for the estimation of the peak junction temperature in power IGBT transistors operating in pulse-width modulation (PWM) controlled DC/AC converters. This approach can be used for the rating of electron devices or heatsink systems in power circuit design, as it provides a direct analytical link, in terms of electrical and thermal device parameters and converter operating conditions between the case and the peak junction temperatures. In this way, by imposing a given upper limit on the junction temperature, indirect constraints on device size or load current or heatsink efficiency can easily be obtained. The approach is based on mild, pessimistic approximations on both the spectrum of dissipated power and on the dynamic thermal behavior of the device. The validity of such approximations has been verified by comparison with the results of accurate numerical simulations carried out by using measurement-based loss models. Possible ways of using this approach in a converter rating context are outlined in the paper, by considering different design scenario

A MACRO sampler

We present results from approximately 2 years running with the MACRO detector. Most of these data were taken with one of the six supermodules of the final detector in operation. Using a sample of 1.8×106 muons with E≳1.4 TeV we have searched for an excess of muons of celestial origin over cosmic ray background. No evidence for steady point sources was found. The upper limit on the muon flux at 95% CL is typically 2×10−12 cm−2 sec−2. No evidence for time modulated point sources was found. The muon multiplicity distribution favors a ‘‘light’’ composition for cosmic ray primaries with ≊75% protons above ∼103 TeV. We have also searched for neutrino bursts from supernovae in our Galaxy. None were observed during the period Oct. 1989 to Feb. 1992. Our sensitivity to neutrino bursts from collapsing stars extends to ≊60% of the stars in the Galaxy.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87712/2/1222_1.pd

Lizards as model organisms of sex chromosome evolution: What we really know from a systematic distribution of available data?

Lizards represent unique model organisms in the study of sex determination and sex chromosome evolution. Among tetrapods, they are characterized by an unparalleled diversity of sex determination systems, including temperature-dependent sex determination (TSD) and genetic sex determination (GSD) under either male or female heterogamety. Sex chromosome systems are also extremely variable in lizards. They include simple (XY and ZW) and multiple (X1X2Y and Z1Z2W) sex chromosome systems and encompass all the different hypothesized stages of diversification of heterogametic chromosomes, from homomorphic to heteromorphic and completely heterochromatic sex chromosomes. The co-occurrence of TSD, GSD and different sex chromosome systems also characterizes different lizard taxa, which represent ideal models to study the emergence and the evolutionary drivers of sex reversal and sex chromosome turnover. In this review, we present a synthesis of general genome and karyotype features of non-snakes squamates and discuss the main theories and evidences on the evolution and diversification of their different sex determination and sex chromosome systems. We here provide a systematic assessment of the available data on lizard sex chromosome systems and an overview of the main cytogenetic and molecular methods used for their identification, using a qualitative and quantitative approach

Dissecting the Extracellular Complexity of Neuromuscular Junction Organizers

Synapse formation is a very elaborate process dependent upon accurate coordination of pre and post-synaptic specialization, requiring multiple steps and a variety of receptors and signaling molecules. Due to its relative structural simplicity and the ease in manipulation and observation, the neuromuscular synapse or neuromuscular junction (NMJ)—the connection between motor neurons and skeletal muscle—represents the archetype junction system for studying synapse formation and conservation. This junction is essential for survival, as it controls our ability to move and breath. NMJ formation requires coordinated interactions between motor neurons and muscle fibers, which ultimately result in the formation of a highly specialized post-synaptic architecture and a highly differentiated nerve terminal. Furthermore, to ensure a fast and reliable synaptic transmission following neurotransmitter release, ligand-gated channels (acetylcholine receptors, AChRs) are clustered on the post-synaptic muscle cell at high concentrations in sites opposite the presynaptic active zone, supporting a direct role for nerves in the organization of the post-synaptic membrane architecture. This organized clustering process, essential for NMJ formation and for life, relies on key signaling molecules and receptors and is regulated by soluble extracellular molecules localized within the synaptic cleft. Notably, several mutations as well as auto-antibodies against components of these signaling complexes have been related to neuromuscular disorders. The recent years have witnessed strong progress in the understanding of molecular identities, architectures, and functions of NMJ macromolecules. Among these, prominent roles have been proposed for neural variants of the proteoglycan agrin, its receptor at NMJs composed of the lipoprotein receptor-related protein 4 (LRP4) and the muscle-specific kinase (MuSK), as well as the regulatory soluble synapse-specific protease Neurotrypsin. In this review we summarize the current state of the art regarding molecular structures and (agrin-dependent) canonical, as well as (agrin-independent) non-canonical, MuSK signaling mechanisms that underscore the formation of neuromuscular junctions, with the aim of providing a broad perspective to further stimulate molecular, cellular and tissue biology investigations on this fundamental intercellular contact